2013 Fiscal Year Final Research Report
Is psychological stress influence the central pain pathway?- The study of the effect of anxiety on central sensitization
| Project/Area Number |
23593009
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IIDA Junichirou 北海道大学, 大学院歯学研究科, 教授 (90151232)
KITAMURA Tetuya 北海道大学, 大学院歯学研究科, 助教 (00451451)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 慢性疼痛 / ストレス / うつ / 不安 / 口腔顔面痛 |
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| Research Abstract |
We investigated the relationship between chronic pain and stress. Rat Chronic contraction injury (CCI) model, which was observed the neuropathic pain behavior was made after SART stress. From our results, there is the relationship between chronic pain and stress synergistically. especially, we investigated the pain behavior not only ipsilateral but also contralateral. Moreover, anxiety and depression behavior also enhance in pain sensation. From our experience, chronic psychological stress induced not only neuropathic pain but also anxiety , depression.
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[Journal Article] Mechanical allodynia but not thermal hyperalgesia is impaired in mice deficient for ERK2 in the central nervous system2012
Author(s)
Yukiko Otsubo a, Yasushi Satoh a,⇑, Mitsuyoshi Kodama a, Yoshiyuki Araki a, Maiko Satomoto b, Eiji Sakamoto a, Gilles Pagès c, Jacques Pouysségur c, Shogo Endo d, Tomiei Kazama
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Journal Title
Pain
Volume: 153(11)
Pages: 2241-52
DOI
Peer Reviewed
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