2013 Fiscal Year Final Research Report
Development of new resin seal in wound healing using activation of innate immunity.
| Project/Area Number |
23593041
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
SAITOH Masato 北海道医療大学, 歯学部, 教授 (50337036)
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| Co-Investigator(Kenkyū-buntansha) |
ABIKO Yoshihiro 北海道医療大学, 歯学部, 准教授 (90260819)
HIKITA Kazuhiro 北海道医療大学, 歯学部, 准教授 (20238281)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 抗菌ペプチド / ビタミンD |
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| Research Abstract |
The present study investigated whether vitamin D affect the promotion of wound healing, and the resistance to bacterial infection as chemical barriers in oral epithelium. Expression of antimicrobial peptides in epithelial keratinocyte cells were upregulated by the stimulation with vitamin D, indicating that vitamin D induced keratinocyte differentiation and barrier function. Wound healing of the rat oral mucosa was promoted to apply ointment supplementation of vitamin D. The results indicate that the application of vitamin D is efficacious of the wound healing and the barrier function in oral epithelium.
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