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2013 Fiscal Year Final Research Report

Mechanisms Linking Periodontitis to Atherosclerotic Diseases

Research Project

  • PDF
Project/Area Number 23593056
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Periodontal dentistry
Research InstitutionNiigata University

Principal Investigator

KOICHI TABETA  新潟大学, 医歯学系, 助教 (20401763)

Co-Investigator(Kenkyū-buntansha) YAMAZAKI Kazuhisa  新潟大学, 医歯学系, 教授 (00182478)
Project Period (FY) 2011 – 2013
Keywords歯周病 / 核酸抗原 / 動脈硬化症
Research Abstract

The aim of this study is to clarify the mechanisms by which oral infection in periodontitis affects systemic disease, especially focusing atherosclerosis. Oral infection induce gut inflammation in low level and enhance atherogenesis. Using unc93b1 mutant, non-responder to nuclear antigens such as DNA and RNA antigens failed to produce IgA against P. gingivalis. Therefore, this study have shown the significance of nuclear antigens in gut immune response to oral infected bacteria.

  • Research Products

    (9 results)

All 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 9 results)

  • [Journal Article] Natural killer T cells mediate alveolar bone resorption and a systemic inflammatory response in response to oral infection of mice with Porphyromonas gingivalis2014

    • Author(s)
      Aoki-Nonaka Y, Nakajima T, Miyauchi S, Miyazawa H, Yamada H, Domon H, Tabeta K, Yamazaki K
    • Journal Title

      J Periodontal Res

      Volume: 49(1) Pages: 69-76

    • Peer Reviewed
  • [Journal Article] Respond to "No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice"2013

    • Author(s)
      Tabeta K, Hoebe K, Janssen EM, Xia Y, Beutler B
    • Journal Title

      Nat Immunol

      Volume: 14(11) Pages: 1102-3

    • Peer Reviewed
  • [Journal Article] Age-related alterations in gene expression of gingival fibroblasts stimulated with Porphyromonas gingivalis2013

    • Author(s)
      Domon H, Tabeta K, Nakajima T, Yamazaki K
    • Journal Title

      J Periodontal Res

    • DOI

      10.111/jre12134

    • Peer Reviewed
  • [Journal Article] A deep intronic mutation in the ankyrin-1 gene causes diminished protein expression resulting in hemolytic anemia in mice2013

    • Author(s)
      Huang H, Zhao P, Arimatsu K, Tabeta K, Yamazaki K, Krieg L, Fu E, Zhang T, Du X
    • Journal Title

      G3 (Bethesda)

      Volume: 3(10) Pages: 1687-95

    • Peer Reviewed
  • [Journal Article] Profiling biomarkers in gingival crevicular fluid using multiplex bead immunoassay2013

    • Author(s)
      Shimada Y, Tabeta K, Sugita N, Yoshie H
    • Journal Title

      Arch Oral Biol

      Volume: 58(6) Pages: 724-30

    • Peer Reviewed
  • [Journal Article] ENU-induced phenovariance in mice : inferences from 587 mutations2012

    • Author(s)
      Arnold CN, Barnes MJ, Berger M, Blasius AL, Brandl K, Croker B, Crozat K, Du X, Eidenschenk C, Georgel P, Hoebe K, Huang H, Jiang Z, Krebs P, La Vine D, Li X, Lyon S, Moresco EM, Murray AR, Popkin DL, Rutschmann S, Siggs OM, Smart NG, Sun L, Tabeta K, Webster V, Tomisato W, Won S, Xia Y, Xiao N, Beutler B
    • Journal Title

      BMC Res Notes

      Volume: 5 Pages: 577

    • Peer Reviewed
  • [Journal Article] Effect of Porphyromonas gingivalis infection on post-transcriptional regulation of the low-density lipoprotein receptor in mice2012

    • Author(s)
      Miyazawa H, Tabeta K, Miyauchi S, Aoki-Nonaka Y, Domon H, Honda T, Nakajima T, Yamazaki K
    • Journal Title

      Lipids Health Dis

      Volume: 11 Pages: 121

    • Peer Reviewed
  • [Journal Article] Relationship between serum antibody titres to Porphyromonas gingivalis and hs-CRP levels as inflammatory markers of periodontitis2012

    • Author(s)
      Miyashita H, Honda T, Maekawa T, Takahashi N, Aoki Y, Nakajima T, Tabeta K, Yamazaki K
    • Journal Title

      Arch Oral Biol

      Volume: 57(6) Pages: 820-9

    • Peer Reviewed
  • [Journal Article] Oral infection with Porphyromonas gingivalis and systemic cytokine profile in C57BL/6.KOR-ApoE shl mice2012

    • Author(s)
      Miyauchi S, Maekawa T, Aoki Y, Miyazawa H, Tabeta K, Nakajima T, Yamazaki K
    • Journal Title

      J Periodontal Res

      Volume: 47(3) Pages: 402-8

    • Peer Reviewed

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Published: 2015-07-16   Modified: 2016-01-27  

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