2013 Fiscal Year Final Research Report
Identification of responsible gene involved with aggressive periodontitis by homozygosity haplotype analysis
| Project/Area Number |
23593061
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAKAMI Hideshi 広島大学, 原爆放射線医科学研究所, 教授 (70253060)
IWATA Tomoyuki 広島大学, 大学病院, 助教 (30418793)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 侵襲性歯周炎 |
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| Research Abstract |
I extracted DNA from patients who had aggressive periodontitis and same family members. I performed a genome-wide scan of single nucleotide polymorphisms by using the Gene Chip and decide the candidate region by using homozygosity haplotype analysis. Two candidate genes which had non-synonymous mutation was listed up by exome sequence using DNA from four patients. Mutations of master mind like 2 exists in candidate region that decided by homozygosity haplotype analysis.
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