2014 Fiscal Year Final Research Report
The regulation of periodontal inflammation based on the inflammasomes activated by periodontal pathogens.
Project/Area Number |
23593066
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Periodontal dentistry
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Research Institution | Fukuoka Dental College (2014) Nagasaki University (2011-2013) |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
HARA Yoshitaka 長崎大学, 大学院医歯薬学総合研究科, 教授 (60159100)
YOSHIMURA Atsutoshi 長崎大学, 大学院石薬学総合研究科, 准教授 (70253680)
|
Project Period (FY) |
2011-04-28 – 2015-03-31
|
Keywords | 歯周病原細菌 / インフラマソーム / NLRP3 / カスパーゼ1 |
Outline of Final Research Achievements |
TInterleukin (IL)-1 is an inflammatory cytokine associated with periodontal break down and alveolar bone resorption, therefore the regulation of IL-1is important to inhibit onset/progression of periodontal disease. IL-1 secretion induced with periodontal pathogens (Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum) is inhibited by the pretreatment with both Ac-YVAD-CMK and glyburide, indicating that IL-1 activation is dependent on both caspase-1 and NLRP3. These results indicate that the possibility of novel periodontal treatment that is targeted for caspase-1 and NLRP3.
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Free Research Field |
歯周病学
|