The regulation of periodontal inflammation based on the inflammasomes activated by periodontal pathogens.

2014 Fiscal Year Final Research Report

• Project/Area Number: 23593066
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Fukuoka Dental College (2014); Nagasaki University (2011-2013)
• Principal Investigator: KANEKO Takashi 福岡歯科大学, 歯学部, 教授 (10284697)
• Co-Investigator(Kenkyū-buntansha): HARA Yoshitaka 長崎大学, 大学院医歯薬学総合研究科, 教授 (60159100) ; YOSHIMURA Atsutoshi 長崎大学, 大学院石薬学総合研究科, 准教授 (70253680)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: 歯周病原細菌 / インフラマソーム / NLRP3 / カスパーゼ１

Outline of Final Research Achievements

TInterleukin (IL)-1 is an inflammatory cytokine associated with periodontal break down and alveolar bone resorption, therefore the regulation of IL-1is important to inhibit onset/progression of periodontal disease. IL-1 secretion induced with periodontal pathogens (Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum) is inhibited by the pretreatment with both Ac-YVAD-CMK and glyburide, indicating that IL-1 activation is dependent on both caspase-1 and NLRP3. These results indicate that the possibility of novel periodontal treatment that is targeted for caspase-1 and NLRP3.

Free Research Field

歯周病学