2013 Fiscal Year Final Research Report
Examination of the effects of periodontitis on aging, and development of novel periodontal treatments
| Project/Area Number |
23593069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUJI Masahiro 北海道医療大学, 教授 (70364271)
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| Project Period (FY) |
2011 – 2013
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| Keywords | Klotho / 老化 / 歯周炎 |
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| Research Abstract |
The purpose of this study was to examine the effects of periodontitis on aging. Periodontitis patients with type 2 diabetes were examined to evaluate the association between inflammation and vascular aging. Periodontal tissue of Klotho mouse was examined to evaluate the association between accelerated aging and periodontitis. Results suggested that inflammation might enhance atherosclerosis through the rapid fluctuation of blood sugar. In addition, gingival fibroblasts from Klotho mouse had reduced growth rate, but enhanced inflammatory responses. These results suggest that periodontitis might affect aging through the systemic inflammation.
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[Journal Article] Effect of glycemic control on periodontitis in type 2 diabetic patients with periodontal disease2013
Author(s)
Katagiri S, Nitta H, Nagasawa T, Izumi Y, Kanazawa M, Matsuo A, Chiba H, Fukui M, Nakamura N, Oseko F, Kanamura N, Inagaki K, Noguchi T, Naruse K, Matsubara T, Miyazaki S, Miyauchi T, Ando Y, Hanada N, Inoue S
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Journal Title
J Diabetes Investig
Volume: 4(3)
Pages: 320-325
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[Journal Article] The anti-phospholipid antibody-dependent and independent effects of periodontopathic bacteria on threatened preterm labor and preterm birth Archives of Gynecology and Obstetrics2013
Author(s)
Ye CC, Katagiri S, Miyasaka N, Bharti P, Kobayashi H, Takeuchi Y, Momohara Y, Sekiguchi M, Takamine S, Nagasawa T, and Izumi Y
Volume
288(1)
Pages
65-72
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[Journal Article] Improvement of glycemic control after periodontal treatment by resolving gingival inflammation in type 2 diabetic patients with periodontal disease2012
Author(s)
Katagiri S, Nagasawa T, Kobayashi H, Takamatsu H, Bharti P, Izumiyama H, Uchimura I, Tagami T, Suzuki T, Nanbara H, Taniguchi Y, Hayakumo S, Koyanagi T, Himeno-Ando A, Goto M, Kajio H, Takahashi Y, Izumi Y, Noda M
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Journal Title
J Diabetes Invest
Volume: 3
Pages: 402-409
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[Journal Article] Modulation of wnt5a expression by periodontopathic bacteria2012
Author(s)
Nanbara H, Wara-Aswapati N, Nagasawa T, Yoshida Y, Yashiro R, Bando Y, Kobayashi H, Khongcharoensuk J, Hormdee D, Pitiphat W, Boch JA, Izumi Y
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Journal Title
PLoS One
Volume: 7(4)
Pages: e34434
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[Journal Article] Reduced masticatory function in non-elderly obese Japanese adults2011
Author(s)
Katagiri S, Nitta H, Nagasawa T, Izumi Y, Kanazawa M, Matsuo A, Chiba H, Miyazaki S, Miyauchi T, Nakamura N, Oseko F, Kanamura N, Ando Y, Hanada N, Inoue S
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Journal Title
Obesity Research and Clinical Practice
Volume: 5
Pages: e279-e286
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