2013 Fiscal Year Final Research Report
Multiple analysis of periodontal condition changes before and after smoking cessation.
| Project/Area Number |
23593072
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
NUMABE yuihiro 日本歯科大学, 生命歯学部, 教授 (90198557)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Hiroshi 日本歯科大学, 生命歯学部, 准教授 (30184683)
ISHIGURO Kazumi 日本歯科大学, 生命歯学部, 助教 (20508486)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 禁煙 / 歯肉溝滲出液 / 好中球 / エラスターゼ / 唾液 / コチニン / 禁煙支援 / 免疫 |
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| Research Abstract |
The relationship between periodontal destruction and smoking has been demonstrated by epidemiological evidence. However the mechanism of this effect is unknown and it may be related to a host defense reaction. The aim of this study is to investigate the effects of smoking cessation on the host defense mechanism in gingival crevicular fluid (GCF) using multiple analysis.
The neutrophil elastase activity in GCF (one of inflammation markers) was measured with a low molecular weight substrate and amount of cotinine in saliva was measured with ELISA. From the results, the elastase activity in GCF was not changed in short term smoking cessation. Furthermore it was shown that temporary smoking cessation does not contribute to an improvement of periodontal tissue and it needs more long period.
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