糖尿病性臓器障害のエネルギ－変化と遺伝子異常

2011 Fiscal Year Research-status Report

• Project/Area Number: 23602012
• Research Institution: Nigata University of Phermacy and Applied Life Sciences
• Principal Investigator: 渡邊 賢一 新潟薬科大学, 薬学部, 教授 (70175090)
• Project Period (FY): 2011-04-28 – 2014-03-31
• Keywords: 国際情報交流 / インド / インドネシア / アメリカ合衆国 / 中国

Research Abstract

糖尿病性臓器障害のメカニズムを研究し下記の学術論文を報告した。(1)Molecular Nutrition & Food Research. 2011 (in press). (2) Pathology International. 2011; 10: 1440-1450. (3) Toxicology. 2011;279,91-99. (4) Pharmaceuticals. 2011; 4: 551-566. (5) European J Pharmacology. 2011; 652:126-135. (6) Biol. Pharm. Bull. 2011; 34:974-979.　 (7) ISRN Pharmacology. 2012 (in press). (8) Free Radical Research.2012(in press). (9) Free Radical Research. 2012 (in press). (10) Hypertension Res. 2012 (in press). (11) Experi Biol Med. 2012 (in press) (12) Heart and Vessels. 2011;26:81-90. (13) Inter J of Biol Scie. 2011;7:154-167. (14) Cell Physiol Biochem. 2011;27:487-496.

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

上記の学術論文を報告した。

Strategy for Future Research Activity

このまま研究を継続する。

Expenditure Plans for the Next FY Research Funding

ラット・マウスなどの実験動物購入と抗体等の購入に使用します。

Research Products

• [Journal Article] Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: Involvement of ACE2-Ang (1-7)-mas axis. (2012)
  • Author(s): .Arumugam S, Watanabe K et al.
  • Journal Title: Toxicology. Volume: 291 Pages: 139-145
  • Peer Reviewed
• [Journal Article] Quercetin offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via endothelin-1/MAPK signaling. (2012)
  • Author(s): Arumugam S, Watanabe K, et al.
  • Journal Title: Free Radic Res. Volume: 46 Pages: 154-163
  • Peer Reviewed
• [Journal Article] Modulation of AT-1R/AMPK-MAPK cascade plays crucial role for the pathogenesis of diabetic cardiomyopathy in transgenic type 2 diabetic (Spontaneous Diabetic Torii) rats. (2012)
  • Author(s): Arun P, Watanabe K, et al.
  • Journal Title: Biochemical Pharmacology Volume: 83 Pages: 653-660.
  • Peer Reviewed
• [Journal Article] Curcumin attenuates diabetic nephropathy by inhibiting PKC-a and PKC-b1 activity in streptozotocin-induced type 1 diabetic rats. (2011)
  • Author(s): Vivian S, Kenichi Watanabe,et al.
  • Journal Title: Mol Nutr Food Res. Volume: 55 Pages: 1655-1665.
  • Peer Reviewed
• [Journal Article] Telmisartan attenuates oxidative stress and renal fibrosis in streptozotocin induced diabetic mice with the alteration of angiotensin-(1-7) mas receptor expression associated with its PPAR-γ agonist action. (2011)
  • Author(s): Arun P, Kenichi Watanabe,et al.
  • Journal Title: Free Radic Res. Volume: 45 Pages: 575-84.
  • Peer Reviewed
• [Journal Article] Telmisartan prevents the progression of renal injury in daunorubicin rats with the alteration of angiotensin II and endothelin-1 receptor expression associated with its PPAR- agonist actions. (2011)
  • Author(s): Wawaimuli A, Watanabe K et al.
  • Journal Title: Toxicology. Volume: 279 Pages: 91-99.
  • Peer Reviewed