2013 Fiscal Year Final Research Report

Involvement of the metabolism pathway of S-Adenosyl methionine in epileptics

Research Project

Project/Area Number	23616007
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	epigenetics
Research Institution	National Institute of Agrobiological Sciences
Principal Investigator	YOSHIKAWA Manabu 独立行政法人農業生物資源研究所, 植物・微生物間相互作用研究ユニット, 主任研究員 (80391564)
Project Period (FY)	2011 – 2013
Keywords	エピジェネティク制御 / S-アデノシルメチオニン
Research Abstract	In epigenetics, cytosines, histones and siRNAs are methylated. S-Adenosyl methionine (SAM) is used as a donor of methyl grope to them. However, it is unknown whether SAM is related to epigenetics in plants. To address this point, I performed this study using Arabidopsis mutants that are defective in SAM metabolisms. I explore transposons that are up-regulated in SAM metabolism defective mutants. I found that a few transposons are up-regulated in the mutants among some transposons. Next I analyzed the status of DNA methylation of up-regulated transposons. These results showed that DNA methylation at a locus is affected in SAM metabolism defective mutants and some epigenetic mutants. This observation implies that SAM metabolism is related to epigenetic regulation.

(5 results)