2013 Fiscal Year Final Research Report
Clinical study of energy metabolism in inflammatory bowel disease
| Project/Area Number |
23617008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
SASAKI Masaya 滋賀医科大学, 医学部, 准教授 (40242979)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 炎症性腸疾患 / クローン病 / 潰瘍性大腸炎 / エネルギー代謝 |
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| Research Abstract |
Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel disease, and patients often suffer from malnutrition. In this study, we examined the energy metabolism of CD and UC patients using indirect calorimetry. There are significant positive correlation between disease activity and resting energy expenditure (REE) in UC patients, and REE significantly decreased after treatment. On the other hand, there are no significant relations between disease activities and REE in CD patients. However, respiratory quotient increased after TNF-a treatment in CD patients. The results of this study suggest that energy metabolism in UC and CD patients could be changed by inflammatory cytokine IL-6.
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Research Products
(4 results)
