2013 Fiscal Year Final Research Report
Action mechanism of functional food and natural medicine focusing on AMP kinase and related signaling molecules in skeletal muscle
| Project/Area Number |
23617009
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Kyoto University |
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Principal Investigator |
HAYASHI Tatsuya 京都大学, 人間・環境学研究科(研究院), 教授 (00314211)
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| Co-Investigator(Renkei-kenkyūsha) |
FUSHIKI Tohru 京都大学, 大学院農学研究科, 教授 (20135544)
INOUE Kazuo 京都大学, 大学院農学研究科, 准教授 (80213148)
TOYODA Taro 京都大学, iPS細胞研究所, 助教 (60593530)
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| Project Period (FY) |
2011 – 2013
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| Keywords | ＡＭＰキナーゼ / 機能性食品 / 生薬 / 骨格筋 / インスリン / 糖輸送 / シグナル伝達 / エネルギー代謝 |
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| Outline of Final Research Achievements |
In the present study we found by using rat skeletal muscle that (1) similar to exercise (muscle contraction), Coptidis rhizoma extract, caffeic acid, salicylate and metformin, all of which have been associated with anti-diabetic properties, acutely stimulate 5'-AMP-activated protein kinase (AMPK) with decreased energy status, (2) caffeine stimulates AMPK, but unlike exercise, concomitantly inhibits insulin receptor signaling, (3) Pu-erh tea extract and its active ingredient gallic acid do not affect AMPK, but stimulate Akt in the absence of insulin, and (4) AMPK activator AICAR has a metabolomic action similar to that of muscle contraction.
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| Free Research Field |
運動生化学, 内分泌代謝学（糖尿病学）
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