2013 Fiscal Year Final Research Report
Anti-obesity mechanism of Pediococcus pentosaceus LP28 and its effect in overweight subjects
| Project/Area Number |
23617013
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Hiroshima University |
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Principal Investigator |
HIGASHIKAWA Fumiko 広島大学, 大学院医歯薬保健学研究院(薬), 特任准教授 (70346534)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIYAMA Masanori 広島大学, 大学院医歯薬保健学研究院 (薬), 教授 (30106801)
NODA Masafumi 広島大学, 大学院医歯薬保健学研究院 (薬), 特任講師 (40457289)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 抗肥満効果 / 植物乳酸菌 / 臨床試験 / 生活習慣病 / メタボリック症候群 |
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| Research Abstract |
Pediococcus pentosaceus LP28 (LP28), which has been isolated from a fruit "longan", has an anti-obesity effect in high fat diet-induced obese mice. The main aim of this study was to investigate whether LP28 is also effective in human. In a double-blind, randomized, placebo-controlled clinical trial, the overweight subjects aged 20-70 years whose BMI was between 25 and 30, were assigned one of the following three groups: placebo; live LP28; or heat-killed LP28. The intake of heat-killed LP28 for 12 weeks reduced BMI, body fat percentage, waist circumference, serum LDL cholesterol level, and LDL/HDL ratio compared with the placebo. Thus, LP28 is effective to improve obesity in human as well as mouse, demonstrating that LP28 will be a very useful tool to reduce the risk of or prevent metabolic syndrome.
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