2013 Fiscal Year Final Research Report
Study of dietary components that have anti-senescence and anti-stress effects in brain
| Project/Area Number |
23617014
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | University of Shizuoka |
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Principal Investigator |
UNNO Keiko 静岡県立大学, 薬学部, 准教授 (10106437)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIURA Minoru 農業生物系特定産業技術研究機構, 果樹研究所, 主任研究官 (10355406)
KONISHI Tomokazu 秋田県立大学, 生物資源科学部, 准教授 (00281650)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脳 / 老化 / 酸化ストレス / 社会心理ストレス |
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| Research Abstract |
Catechins in green tea and beta-cryptoxanthin in Japanese mandarin orange suppressed senescence and age-related brain dysfunction in aged mice. The effective dose of these components suggests that green tea catechin and beta-cryptoxanthin prevent age-related brain dysfunction in human. Although accumulation of psychosocial stress accelerated brain senescence in mice, theanine, an amino acid in tea, suppressed stress-related brain dysfunction. Theanine had significant anti-stress effect in university students during pharmacy practice, suggesting that theanine prevents stress-related brain dysfunction in human.
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[Journal Article] Anti-stress effect of theanine on students during pharmacy practice : Positive correlation among salivaryα-amylase activity, trait anxiety and subjective stress2013
Author(s)
Unno K, Tanida N, Ishii N, Yamamoto H, Iguchi K, Hoshino M, Takeda A, Ozawa H, Ohkubo T, Juneja LR, Yamada H
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Journal Title
Pharmacol Biochem Behav
Volume: 111
Pages: 128-135
DOI
Peer Reviewed
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[Journal Article] Ingestion of theanine, an amino acid in tea, suppresses psychosocial stress in mice2013
Author(s)
Unno K, Iguchi K, Tanida N, Fujitani K, Takamori N, Yamamoto H, Ishii N, Nagano H, Nagashima T, Hara A, Shimoi K, Hoshino M.
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Journal Title
Exp Physiol
Volume: 98
Pages: 290-303
DOI
Peer Reviewed
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[Journal Article] Active Component in Green Tea Catechins and Effective Intake Period for Prevention of Age-related Brain Dysfunction2011
Author(s)
Unno K, Yamamoto H, Ohtaki T, Ishikawa Y, Noda S, Maeda K, Fujitani K, Miyazaki H, Takabayashi F, Sasaki T, Hoshino M
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Journal Title
Anti-Aging Medicine
Volume: 8
Pages: 75-81
URL
Peer Reviewed
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[Journal Article] Theanine intake improves the shortened lifespan, cognitive dysfunction and behavioral depression that are induced by chronic psychosocial stress in mice2011
Author(s)
Unno K, Fujitani K, Takamori N, Takabayashi F, Maeda K, Miyazaki H, Tanida N, Iguchi K, Shimoi K, Hoshino M
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Journal Title
Free Radical Res.
Volume: 45
Pages: 966-974
DOI
Peer Reviewed
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[Journal Article] Beta-Cryptoxanthin, Plentiful in Japanese Mandarin Orange, Prevents Age-related Cognitive Dysfunction and Oxidative Damage in Senescence-accelerated Mouse Brain2011
Author(s)
Unno K, Sugiura M, Ogawa K, Takabayashi F, Toda M, Sakuma M, Maeda K, Fujitani K, Miyazaki H, Yamamoto H, Hoshino M
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Journal Title
Biol. Pharm. Bull
Volume: 34
Pages: 311-317
URL
Peer Reviewed
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