2013 Fiscal Year Final Research Report
The mechanisms of muscle wasting and its treatment in chronic kidney diseases
| Project/Area Number |
23617015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | University of Shizuoka |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 栄養障害 / 骨格筋 / 筋萎縮 / 筋蛋白 / テストステロン / プロテアソーム |
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| Research Abstract |
The skeletal muscle atrophy is a serious complication of chronic kidney diseases (CKD). This study has been conducted to elucidate the mechanism of muscle atrophy and to establish the treatment of this complication in CKD. In rats with renal failure, the muscle atrophy was induced by the suppression of muscle protein synthesis while the influence of protein restriction for treating renal failure was small. Serum testosterone and proteasome concentrations were useful indicators for muscle mass in dialysis patients. In conclusion, the improvement of uremic condition is one of the strategies to prevent muscle atrophy, and these biomarkers of muscle metabolism were useful for expecting muscle atrophy in CKD.
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