2013 Fiscal Year Final Research Report
Molecular regulation analysis of bone-blood vessel correlation and development of CKD nutrition therapy
| Project/Area Number |
23617019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | University of Hyogo |
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Principal Investigator |
ITO Mikiko 兵庫県立大学, 環境人間学部, 准教授 (50314852)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAUE Motoyoshi 兵庫県立大学, 環境人間学部, 教授 (20283913)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 慢性腎蔵病 / 血管石灰化 / 破骨細胞 / 血液透析 / 高リン血症 |
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| Research Abstract |
The hyperphosphatemia is observed at high ratio in the hemodialysis patients, and the phosphate (Pi) management is important because this leads of one's death by the cardiovascular disease by the ectopic calcification. Especially, Pi sensor and Pi channel are key protein to clear the ectopic calcification in bone. In this research, we tried to clarify the calcification mechanism by characterization of the Pi channel in the bone and/or the vascular endothelial.
In this research, we indicated the molecular regulation and function of Pi channel and role of the ectopic calcification in calcificated Human Aortic Smooth Muscle Cells.
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Research Products
(25 results)
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[Journal Article] Hepatectomy-Related Hypophosphatemia : A Novel Phosphaturic Factor in the Liver-Kidney Axis2014
Author(s)
Nomura K, Tatsumi S, Miyagawa A, Shiozaki Y, Sasaki S, Kaneko I, Ito M, Kido S, Segawa H, Sano M, Fukuwatari T, Shibata K, Miyamoto KI
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Journal Title
J Am Soc Nephrol
Volume: 25(4)
Pages: 761-72
DOI
Peer Reviewed
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[Journal Article] Identification and functional analysis of a splice variant of mouse sodium-dependent phosphate transporter Npt2c2012
Author(s)
Kuwahara S, Aranami F, Segawa H, Onitsuka A, Honda N, Tominaga R, Hanabusa E, Kaneko I, Yamanaka S, Sasaki S, Ohi A, Nomura K, Tatsumi S, Kido S, Ito M, Miyamoto K
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Journal Title
J Med Invest
Volume: 59 (1-2)
Pages: 116-26
URL
Peer Reviewed
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[Journal Article] Processing and stability of type IIc sodium-dependent phosphate cotransporter mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria2012
Author(s)
Haito-Sugino S, Ito M, Ohi A, Shiozaki Y, Kangawa N, Nishiyama T, Aranami F, Sasaki S, Mori A, Kido S, Tatsumi S, Segawa H, Miyamoto KI
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Journal Title
Am J Physiol Cell Physiol
Volume: 302(9)(同列筆著者)
Pages: C1316-30
DOI
Peer Reviewed
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[Journal Article] Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats2011
Author(s)
Ishisaka A, Ichikawa S, Sakakibara H, Piskula MK, Nakamura T, Kato Y, Ito M, Miyamoto KI, Tsuji A, Kawai Y, Terao J
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Journal Title
Free Radic Biol Med
Volume: 51(7)
Pages: 1329-36
DOI
Peer Reviewed
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[Journal Article] Sodium-dependent phosphate cotransporters : Lessons from gene knockout and mutation studies2011
Author(s)
Miyamoto K, Haito-Sugino S, Kuwahara S, Ohi A, Nomura K, Ito M, Kuwahata M, Kido S, Tatsumi S, Kaneko I, Segawa H
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Journal Title
J Pharm Sci
Volume: 100(9)(Review)
Pages: 3719-3730
DOI
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[Presentation] Molecular Consequences of the SLC34A3 Mutations of Hereditary Hypophosphatemic Rickets with Hypercalciuria (HHRH)2011
Author(s)
Akiko Ohi, Sakiko Haito Sugino, Mikiko Ito, Yuji Shiozaki, Kengo Nomura, Yuri Kusaka, Shohei Sasaki, Saori Ohnishi, Seiichi Yamaguchi, Shinsuke Kido, Sawako Tatsumi, Hiroko Segawa, Ken-ichi Miyamoto
Organizer
The American Society of Nephrology(ASN)
Place of Presentation
Pennsylvania Convention Center Philadelphia(U.S.A.)
Year and Date
20111108-13
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[Book] 創訳応用研究の最新成果, リン酸トランスポーター関連分子群とリン代謝異常症,トランスポートソーム生体膜輸送機構の全体像に迫る−基礎,臨床2011
Author(s)
桑原頌治,西山俊,大井彰子,金子一郎,辰巳佐和子,伊藤美紀子,竹谷豊,宮本賢一, (金井好克編集)
Total Pages
280, (244-248)
Publisher
メディカルドゥ
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