2013 Fiscal Year Final Research Report
Prevention of human hepatoma with acyclic retinoids
| Project/Area Number |
23617020
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | University of Nagasaki |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | オートファジー / 非環式レチノイド / ゲラニルゲラノイン酸 / オートファゴソーム / 細胞死 / 癌予防 |
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| Research Abstract |
Cellular mechanism underlying acyclic retinoid of geranylgeranoic acid (GGA)-mediated induction of cell death in human hepatoma cells was investigated. In hepatoma cells, GGA induces initial autophagy, but incomplete autophagic response, which lacks autolysosome formation. As a cellular mechanism of GGA-induced initial autophagy, we observed 1) nuclear translocation of mutant p53, 2) hyperproduction of superoxide, and 3) unfolded protein response (UPR) in ER. The present study revealed that GGA induces initial autophagy through ER-UPR, which may result in cell death.
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[Journal Article] CXCR4-tropic, but not CCR5-tropic, human immunodeficiency virus infection is inhibited by the lipid raft-associated factors, acyclic retinoid analogs, and cholera toxin B subunit2013
Author(s)
Kamiyama H, Kakoki K, Shigematsu S, Izumida M, Yashima Y, Tanaka Y, Hayashi H, Matsuyama T, Sato H, Yamamoto N, Sano T, Shidoji Y, Kubo Y.
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Journal Title
AIDS Res Hum Retroviruses
Volume: 29
Pages: 279-288
Peer Reviewed
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[Remarks] ホームページ等準備中
