2014 Fiscal Year Final Research Report
Epigenetic regulation of placental function by maternal nutrition as a mechanism of disease in DOHaD
| Project/Area Number |
23617021
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Fuji Women's University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEBE Kumiko 藤女子大学, 人間生活学部, 教授 (60439495)
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| Research Collaborator |
BAY Jacquie LENScience, Director
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Keywords | DOHaD |
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| Outline of Final Research Achievements |
Developmental Origins of Health and Disease (DOHaD) hypothesis, whereby noncommunicable diseases (NCDs) including Type 2 diabetes, myocardial infarction, and stroke have been demonstrated to be influenced by the parents' biological environments; diet, exercise, etc., from pregnancy to about 2 years of age. We here hypothesised that epigenetic regulation of placental proteins by maternal nutrition plays important roles as a mechanism of DOHaD-related disease and that gap junctional proteins connexins are among those placental proteins. We published a paper showing that the expression of connexins is regulated by epigenetic mechanisms. In Japan, the percentage of low-birth-weight (<2,500 g) newborns has increased and more than 20% of women in their twenties are underweight (BMI, <18.5). These data have raised concern that chronic adult diseases related to DOHaD may further increase in the future. Thus, we have started researches on dissemination of the DOHaD concept among young Japanese.
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| Free Research Field |
DOHaD
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