2013 Fiscal Year Final Research Report
Study of the mechanism of obesity-associated infertility in male and search for nutrient component improving obesity associated infertility
| Project/Area Number |
23617023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Wayo Women's University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | 雄性不妊 / 肥満 / 高脂肪食 / 精巣 / 精巣上体 |
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| Research Abstract |
Human studies have shown a direct relationship between obesity and infertility in men and women. In the present study, we examined the mechanism of infertility by high fat diet-induced obesity in male mice. In addition, we examined whether L-carnitine can improve male infertility with diet-induced obesity. High fat diet-obesity resulted in decreased sperm motility and reduction in pregnancies of female partners. L-carntine supplementation itself did not seem to improve obesity-associated male infertility in male mice. Gene expression analysis of cauda epididymides suggested that DNA damage is increased in the sperm cells during spermatogenesis and/or sperm maturation in diet-induced obesity male mice and decreased expression of piRNA might be involved in the increased DNA damage in sperm.
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[Journal Article] 11. Cytotoxicity of tap and first-class-river water in eastern Japan2011
Author(s)
Qian Ren, Xia Jiang, Shi-Ping Chen, Masataka Yoshida, Xiao-Bo Tong, Wen-Zhi Guo, Toshikazu Suzuki, Shigeru Sugaya, Takeshi Tanaka, Kazuko Kita, Nobuo Suzuki
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Journal Title
Chiba Medical Journal
Volume: 87
Pages: 189-194
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