2013 Fiscal Year Final Research Report
The transport of polyunsaturated fatty acids across the placenta to the fetus and the subsequent growth and development of the infant
| Project/Area Number |
23617025
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Kagawa Nutrition University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAI Kunihiko 東北大学, 大学院医学系研究科, 教授 (00291336)
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| Project Period (FY) |
2011 – 2013
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| Keywords | n-3系多価不飽和脂肪酸 / 母児間移行 / n-6系多価不飽和脂肪酸 / 臍帯血 / 母体血 |
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| Research Abstract |
We analyzed the polyunsaturated fatty acid (PUFA) compositions in maternal and cord blood erythrocytes of 523 pregnant women living along the shore of the Miyagi prefecture and determined the transport of arachidonic acid (ARA) and docosahexaenoic acid (DHA) across the placenta to the fetus. The PUFA levels of infants reflected those of their mothers, indicating that PUFA transport across the placenta to the fetus determined the PUFA compositions in cord blood erythrocytes. In the third trimester, the ARA level in maternal erythrocytes decreased compared with that in the second trimester, but no change in maternal DHA was observed. This finding suggested that the DHA in maternal blood satisfied the increasing demand of the fetus in the third trimester.
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