2013 Fiscal Year Final Research Report
Study of effect of personalized nutrition with genotype announcement in health promotion
| Project/Area Number |
23617026
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Shukutoku University (2013)
Kagawa Nutrition University (2011-2012) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | テーラーメイド栄養指導 / 葉酸 / ホモシステイン / 遺伝子多型 / 葉酸摂取量 / 健康づくり |
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| Research Abstract |
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism affects plasma homocysteine level and is genetic risk factor for atherosclerosis, cardiovascular disease, and cognitive impairment. I verified the effect of personalized nutrition in folate status with genotype announcement in "Sakado folate projects". Subjects could generally accept the genotype announcement. Serum folate levels, serum homosystein levels and folate intake were improved for six months in regardless MTHFR genotypes. The subjects with TT genotype or those given the multiple nutrition guidance could continue the improved folate status for long term.
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