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2014 Fiscal Year Final Research Report

Roles of fat-soluble nutrients in the development of neural circuits supporting parental infant relationship.

Research Project

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Project/Area Number 23617034
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrated Nutrition Science
Research InstitutionYasuda Women's University

Principal Investigator

MORITA Noriyuki  安田女子大学, 家政学部, 准教授 (50239662)

Project Period (FY) 2011-04-28 – 2015-03-31
Keywords視床下部 / 縫線核 / トコトリエノール / エストロゲン受容体 / 小脳 / 脳スライス培養 / in situ ハイブリダイゼーション / 免疫組織化学
Outline of Final Research Achievements

Fostering ties between parents and children, and nurturing loving and committed relationships are fundamental to healthy dietary habit over a lifetime. Focusing on the hypothalamus and other brain regions involved in maternal, attachment, and anxiety-like behaviors, the effects of fat-soluble nutrients on neurogenesis and functional development of the neural circuits were investigated in mice.
Using single living cell imaging analysis of GFP-tagged estrogen receptor beta, natural fat-soluble vitamin E tocotrienols were evaluated to act as ligand for the receptor. The effects of tocotrienols on neuronal differentiation are under investigation in either postnatal cerebellar or embryonic hypothalamic slice culture system.

Free Research Field

神経発生学

URL: 

Published: 2016-06-03  

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