Development of a novel treatment with fetal membrane-derived mesenchymal stem cells to enteritis by chemoradiation

2013 Fiscal Year Final Research Report

• Project/Area Number: 23618001
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Regenerative medicine
• Research Institution: Hokkaido University
• Principal Investigator: Ohnishi Shunsuke 北海道大学, 医学(系)研究科(研究院), 助教 (10443475)
• Project Period (FY): 2011 – 2013
• Keywords: 間葉系幹細胞 / 卵膜 / 放射線腸炎

Outline of Final Research Achievements

Radiation enteritis is caused by radiation therapy to cancer patients, or by an accident in nuclear power plants. The aim of the study was to explore the new strategy to treat radiation enteritis, and I investigated the effect of fetal membrane-derived mesenchymal stem cells in vivo and in vitro.
Treatment with human amnion-derived mesenchymal stem cells in rats with radiation enteritis ameliorated histological observations and the expression of proinflammatory cytokines. In vitro experiments demonstrated that radiation-induced cell injury was suppressed by human amnion-derived mesenchymal stem cells.
Taken together, amnion-derived mesenchymal cells could be considered as a new treatment for radiation enteritis.

Free Research Field

再生医学・医療