2014 Fiscal Year Final Research Report
Involvement of FactorXIII-A in fish optic nerve regeneration
| Project/Area Number |
23618006
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Regenerative medicine
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KORIYAMA Yoshiki 鈴鹿医療科学大学, 薬学部, 准教授 (70397199)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KATO Satoru 金沢大学, 医学系, 教授 (10019614)
|
|---|
| Project Period (FY) |
2011-04-28 – 2015-03-31
|
| Keywords | Factor XIII-A / retina / optic nerve / regeneration / neurite sprouting / neurite outgrowth |
|---|
| Outline of Final Research Achievements |
Unlike mammals, fish retinal ganglion cells have the capacity to repair their axons even after optic nerve transection. In the process of fish optic nerve regeneration, a large number of genes have been described as regeneration-associated molecules. Using molecular cloning techniques, we identified some cDNA clones belonging to the transglutaminase (TG) family as upregulation genes, and one of those was Factor XIII A subunit (FXIII-A). FXIII-A is quickly activated after optic nerve lesion and deeply involved in wound healing and optic nerve regeneration.
|
| Free Research Field |
神経化学
|
