2013 Fiscal Year Final Research Report
Safety and effectiveness of neural stem cells directly induced from skin fibroblasts
| Project/Area Number |
23618010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Regenerative medicine
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| Research Institution | Keio University |
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Principal Investigator |
AKAMATSU WADO 慶應義塾大学, 医学部, 講師 (60338184)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 神経幹細胞 / ダイレクトリプログラミング |
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| Research Abstract |
We succeeded in making human directly induced neural stem cells by using Sendai virus vectors. Although we were able to obtain increased number of neurospheres compared to retroviral vectors, SeV-induced neurospheres did not differentiate into neural cells efficiently.
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[Journal Article] Involvement of ER Stress in Dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 Missense Mutations Shown by iPSC-Derived Oligodendrocytes2014
Author(s)
Numasawa-Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Oasaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H
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Journal Title
Stem Cell Rep
Volume: 2
Pages: 1-14
DOI
Peer Reviewed
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[Journal Article] The RNA binding protein, HuD regulates autophagosome formation in pancreatic βcells by promoting autophagy-related gene 5 expression2014
Author(s)
Kim C, Kim W, Lee H, Ji E, Choe YJ, Martindale JL, Akamatsu W, Okano H, Kim HS, Nam SW, Gorospe M, Lee EK
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Journal Title
J Biol Chem
Volume: 289(1)
Pages: 112-21
DOI
Peer Reviewed
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[Journal Article] Increased Ll Retrotransposition in the neuronal genome in Schizo phrenia2014
Author(s)
Bundo M, Toyoshima M, Ueda J, Nemoto-Miyake T, Sunaga F, Toritsuka M, Ikawa D, Kakita A, Okada Y, Akamatsu W, Kato M, Okano H, Kasai K, Kishimoto T, Nawa H, Yoshikawa T, Kato T, Iwamoto K
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Journal Title
Neuron
Volume: 81(2)
Pages: 306-13
DOI
Peer Reviewed
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[Journal Article] A human Dravet syndrome model from patient induced pluripotent stem cells2013
Author(s)
Higurashi N, Uchida T, Christoph L, Misumi Y, Okada Y, Akamatsu W, Imaizumi Y, Zhang B, Nabeshima K, Mori M, Katsurabayashi S, Shirasaka S, Okano H and Hirose S
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Journal Title
Mol Brain
Volume: 6(1)
Pages: 19
DOI
Peer Reviewed
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[Journal Article] Mitochondrial dysfunction associated with increased oxidative stress and alpha-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue2012
Author(s)
Imaizumi Y, Okada Y, Akamatsu W, Koike M, Kuzumaki N, Hayakawa H, Nihira T, Kobayashi T, Ohyama M, Sato S, Takanashi M, Funayama M, Hirayama A, Soga T, Hishiki T, Suematsu M, Yagi T, Ito D, Kosakai A, Hayashi K, Shouji M, Nakanishi A, Suzuki N, Mizuno Y, Mizushima N, Amagai M, Uchiyama Y, Mochizuki H, Hattori N, Okano H
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Journal Title
Mol Brain
Volume: 5(1)
Pages: 35
DOI
Peer Reviewed
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[Journal Article] Derivation of induced pluripotent stem cells by retroviral gene transduction in mammalian species2012
Author(s)
Imamura M, Okuno H, Tomioka I, Kawamura Y, Lin ZY, Nakajima R, Akamatsu W, Okano HJ, Matsuzaki Y, Sasaki E, Okano H
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Journal Title
Methods Mol Biol
Volume: 925
Pages: 21-48
DOI
Peer Reviewed
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[Journal Article] Establishment of induced pluripotentstem cells from centenarians for neurodegenerative disease research2012
Author(s)
Yagi T, Kosakai A, Ito D, Okada Y, Akamatsu W, Nihei Y, Nabetani A, Ishikawa F, Arai Y, Hirose N, Okano H, Suzuki N
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Journal Title
PLoS One
Volume: 7(7)
Pages: e41572
DOI
Peer Reviewed
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[Journal Article] RNA-binding protein HuD controls insulin translation2012
Author(s)
Lee EK, Kim W, Tominaga K, Martindale JL, Yang X, Subaran SS, Carlson OD, Mercken EM, Kulkarni RN, Akamatsu W, Okano H, Perrone-Bizzozero NI, de Cabo R, Egan JM, Gorospe M
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Journal Title
Mol Cell
Volume: 45 (6)
Pages: 826-35
DOI
Peer Reviewed
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