2013 Fiscal Year Final Research Report
Regeneration of islets used tissue engineering
| Project/Area Number |
23618012
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Regenerative medicine
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHINAKAMURA Hitomi 福岡大学, 膵島研究所, ポストドクター (90597692)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 組織工学的膵島 / 膵島再生 / 組織工学 / 再生医学・再生医療 / 膵島移植 / 血管再生 / 生体材料 / 糖尿病 |
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| Research Abstract |
Tissue engineered(TE) islets were reconstructed from dissociated islet cells originated from transgenic mice that expressed green fluorescence protein in mouse insulin promoter area. Although the reconstructive ratio of islets number was improved from 30% to 68%, it was not exceeded as primary number of native islets from one mouse. However, it was surprised that the content of insulin protein per DNA ratio was increased two fold up in TE islets.
Continuously, diabetic mice were transplanted TE islets under kidney capsule. TE islets ameliorated blood glucose levels using half number of islet cells to compare with native islets.
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[Journal Article] Pretreatment of donor islets with the Na+/Ca2+ exchanger inhibitor improves the efficiency of islet transplantation2013
Author(s)
Mera T., Itoh T., Kita S., Kodama S. Kojima D., Nishinakamura H., Okamaoto K., Ohkura M., Nakai J., Iyoda T., Iwamoto T., Matsuda T., Baba A., Omori K., MullenY., Ono L., Watari H., Taniguchi M., Yasunami T.
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Journal Title
Am J Transplant
Volume: 13(8)
Pages: 2154-60
Peer Reviewed
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