2011 Fiscal Year Final Research Report
Exploration of Fundamental Principle of Robustness and Adaptability of Biological Functional Systems
| Project/Area Number |
23650115
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sensitivity informatics/Soft computing
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2011
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| Keywords | カオス / 生物物理 / ネットワーク / 情報数理 / 複雑系 |
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| Research Abstract |
To unveil the question of "how can complex systems adapt to the environmental changes and provide functions robustly in a thermal fluctuating world" on the basis of novel data-driven approach, two novel methods are developed : The one can extract the underlying physical quantity from a noisy single molecule time series whose noise is represented in terms of any probability distribution function, and the other can quantify higher order correlation among multivariate variables and identify irreducible information theoretic modular structure. We showed that the most conventionally used data analysis for single molecule biophysics(enzymatic reactions) led us to a physically incorrect interpretation.
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