Analysis of differentiation/dedifferentiation dynamics of undifferentiated cells using mathematical modeling

2012 Fiscal Year Final Research Report

• Project/Area Number: 23650152
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Bioinformatics/Life informatics
• Research Institution: The Institute of Physical and Chemical Research (2012); Osaka University (2011)
• Principal Investigator: FURUSAWA Chikara 独立行政法人理化学研究所, 多階層生命動態研究チーム, チームリーダー (00372631)
• Project Period (FY): 2011 – 2012
• Keywords: 幹細胞 / 分化 / 数理モデル / 計算機シミュレーション / 安定性

Research Abstract

The purpose of this study is to understand differentiation dynamics of stem cells using computational models. We screened gene regulatory networks which can generate stem cell differentiation dynamics to identify general features of the differentiation dynamics. As results, we found that stem cells generally have oscillatory expression dynamics, and also identified characteristics of regulatory networks generating such differentiation dynamics. Based on these understandings, we constructed a computational model to represent differentiation dynamics in mouse early development.

Research Products

• [Journal Article] A dynamical-systems view of stem cell biology (2012)
  • Author(s): Chikara Furusawa, Kunihiko Kaneko
  • Journal Title: Science Volume: 338(6104) Pages: 215-217
  • DOI: DOI:10.1126/science.1224311
  • Peer Reviewed
• [Journal Article] Adaptation to optimal cell growth through self-organized criticality (2012)
  • Author(s): Chikara Furusawa, Kunihiko Kaneko
  • Journal Title: Phys. Rev. lett Volume: 108 Pages: 208103
  • DOI: DOI:10.1103/PhysRevLett.108.208103
  • Peer Reviewed
• [Journal Article] Oscillatory protein expression dynamics endows stem cells with robust differentiation potential (2011)
  • Author(s): Narito Suzuki, Chikara Furusawa, Kunihiko Kaneko
  • Journal Title: PLoS One Volume: 6(11) Pages: e27232
  • Peer Reviewed
• [Journal Article] Epigenetic feedback regulation accelerates adaptation and evolution
  • Author(s): Chikara Furusawa, Kunihiko Kaneko
  • Journal Title: PLoS One Volume: 8(5) Pages: e61251
  • DOI: DOI:10.1371/journal.pone.0061251
  • Peer Reviewed
• [Presentation] 生物システムの多階層性を (理論/実験)から理解する (2013)
  • Author(s): 古澤力
  • Organizer: 生物物理若手の会関西支部セミナー
  • Place of Presentation: 大阪
  • Year and Date: 2013-03-16
• [Presentation] 生命システムの可塑性と安定性の理解へ向けて (2013)
  • Author(s): 古澤力
  • Organizer: 第1回NINS Colloquium「自然科学の将来像」
  • Place of Presentation: 箱根
  • Year and Date: 2013-02-05
• [Presentation] 細胞間コミュニケーションによる細胞社会の自己組織化ダイナミクス (2012)
  • Author(s): 古澤力
  • Organizer: 第4回NetSci研究会
  • Place of Presentation: 大阪
  • Year and Date: 2012-12-04
• [Presentation] 幹細胞のシステムバイオロジー:細胞分化の動的モデル (2012)
  • Author(s): 古澤力
  • Organizer: 横浜市立大学医学研究科大学院医学セミナー
  • Place of Presentation: 横浜
  • Year and Date: 2012-10-04
• [Presentation] A dynamical system modeling of cell differentiation for understanding of robust development and cell reprogramming (2012)
  • Author(s): 古澤力, 金子邦彦
  • Organizer: 日本生物物理学会第50回年会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-22
• [Presentation] Oscillatory protein expression dynamics generates robust and irreversible differentiation dynamics of stem cells (2012)
  • Author(s): Chikara Furusawa
  • Organizer: 4th International Congress on Stem Cells and Tissue Formation
  • Place of Presentation: Dresden, Germany
  • Year and Date: 2012-07-19
• [Presentation] Temporal oscillation in protein expressions generates robust differentiation dynamics of stem cells (2012)
  • Author(s): Chikara Furusawa
  • Organizer: 11th Annual Meeting of International Socienty for Stem Cell Research
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2012-06-12
• [Remarks] 古澤力, 西宮湯川記念賞, 2011年11月 受賞
• [Remarks] 古澤力, 文部科学大臣表彰 若手科学者賞, 2011年4月 受賞