2012 Fiscal Year Final Research Report
Real-time and multi-color imaging of synapse elimination in the CNS.
| Project/Area Number |
23650160
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | The University of Tokyo |
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Principal Investigator |
UESAKA Naofumi 東京大学, 大学院・医学系研究科, 助教 (70597624)
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| Project Period (FY) |
2011 – 2012
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| Keywords | シナプス刈り込み / 小脳 / プルキンエ細胞 / 登上線維 / 蛍光タンパク質 / レンチウィルス / イメージング |
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| Research Abstract |
During brain development, immature redundant neural circuitry is refined into functionally mature versions through the process known as “synapse elimination”. However, how synapse elimination proceeds is largely unknown. In this study, we have developed the method for multi-color labeling of cells and synapses by various fluorescent proteins like green fluorescent protein(GFP), and real-time imaging of these cells and synapses.
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