2012 Fiscal Year Final Research Report
Activity-dependent dynamics of replication-dependent core histones in post-mitotic neurons
| Project/Area Number |
23650167
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | Gunma University |
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Principal Investigator |
TAKIZAWA Takumi 群馬大学, 大学院・医学系研究科, 准教授 (30531115)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 分子・細胞神経科学 / クロマチン / ヒストン / 神経活動依存性転写 |
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| Research Abstract |
In mature post-mitotic neurons derived from mouse hippocampus, a hist1h3f gene, which encodes replication-dependent core histone H3.2, is expressed upon stimulation to glutamine receptors. Salt extraction and metabolic labeling of newly synthesized proteins in neurons revealed that core histone proteins are increased at protein levels in responseto glutamine receptor stimulation. These results suggest that newly synthesized replication dependent core histones play a role in post-mitotic neurons.
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[Journal Article] Role of GLI2 in the growth of human osteosarcoma2011
Author(s)
Nagao, H., Ijiri, K., Hirotsu, M., Ishidou, Y., Yamamoto, T., Nagano, S., Takizawa, T., Nakashima, K., Komiya, S. & Setoguchi, T.
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Journal Title
J Pathol
Volume: 224
Pages: 169-179
Peer Reviewed
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