The expression system specific for the circadian center

2012 Fiscal Year Final Research Report

• Project/Area Number: 23650177
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Hiroshima University
• Principal Investigator: TAKUMI Toru 広島大学, 大学院・医歯薬保健学研究院, 教授 (00222092)
• Project Period (FY): 2011 – 2012
• Keywords: 遺伝子 / 細胞・組織 / 行動学 / 神経科学

Research Abstract

The mammalian oscillator for circadian rhythm with a period of 24 hours is localized in the suprachiasmatic nucleus (SCN). Although the recent advance in genetic engineering methods provide different region-specific expression system, we have not obtained the specific expression system in SCN. The present study is to try to establish a system of SCN-specific expression using a combination of different promoters.

Research Products

• [Journal Article] Characterization and modeling of intermittent locomotor dynamics in clock-deficient mice (2013)
  • Author(s): Nakamura, T., Takumi, T., Takano, A., Hatanaka, F. and Yamamoto, Y
  • Journal Title: PLoS ONE Volume: 8 Pages: e58884
  • Peer Reviewed
• [Journal Article] Period coding of Bmal1 oscillators in the suprachiasmatic nucleus (2012)
  • Author(s): Myung, J., Hong, S., Hatanaka, F., Nakajima, Y., De Schutter, E. and Takumi, T
  • Journal Title: J. Neurosci Volume: 32 Pages: 8900-8918
  • Peer Reviewed
• [Journal Article] Differential patterns in the periodicity and dynamics of clock gene expression in mouse liver and stomach (2012)
  • Author(s): Mazzoccoli, G., Francavilla, M., Pazienza, V., Piepoli, A., Benegiamo, G., Vinciguerra, M, Giuliani, F., Yamamoto, T. and Takumi, T
  • Journal Title: Chronobiol. Int Volume: 29 Pages: 1300-1311
  • Peer Reviewed
• [Journal Article] REV -ERBa and the clock gene machinery in mouse peripheral tissues: a possible role as a synchronizing hing (2012)
  • Author(s): Mazzoccoli, G., Cai, Y., Liu, M., Francavilla, M., Giuliani, F., Piepoli, A., Pazienza, V., Vinciguerra, M, Yamamoto, T. and Takumi, T
  • Journal Title: J. Biol. Regul. Homeost. Agents Volume: 26 Pages: 265-276
  • Peer Reviewed
• [Presentation] A molecular link between mood and circadian clock (2012)
  • Author(s): Toru Takumi
  • Organizer: 第85回日本生化学会大会シンポジウム「Biochemistry of mind」
  • Place of Presentation: 福岡
  • Year and Date: 20121214-16
• [Presentation] 概日リズムと医学研究 (2012)
  • Author(s): 内匠透
  • Organizer: 第24回日本脳循環代謝学会総会
  • Place of Presentation: 広島
  • Year and Date: 20121108-09
• [Presentation] 時計遺伝子 Per2 と気分 (2012)
  • Author(s): 内匠透
  • Organizer: 第34回日本生物学的精神医学会シンポジウム「分子遺伝学の鍵分子からみた精神疾患」
  • Place of Presentation: 神戸
  • Year and Date: 20120928-30
• [Presentation] リズムと気分 (2012)
  • Author(s): 内匠透
  • Organizer: 第19回日本時間生物学会学術大会シンポジウム「精神疾患の時間生物学的基盤」
  • Place of Presentation: 札幌
  • Year and Date: 20120915-16
• [Presentation] Circadian Network of Bmal1 (2012)
  • Author(s): Toru Takumi
  • Organizer: Circadian Network of Bmal1
  • Place of Presentation: Destin, FL, USA
  • Year and Date: 20120519-23
• [Presentation] Molecular links between rhythm and mood (2012)
  • Author(s): Toru Takumi
  • Organizer: 1stSwiss Chronobiology Meeting
  • Place of Presentation: Fribourg, Switzerland
  • Year and Date: 2012-09-06
• [Presentation] 気分障害と概日時計を結ぶリチウム (2012)
  • Author(s): 内匠透
  • Organizer: 第31回リチウム研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-14
• [Presentation] The phosphorylation of PERIOD2 via glycogen synthase kinase 3b has the possibility of the regulator in the depression-like behavior (2011)
  • Author(s): Yousuke Yamawaki, Atsuko Takano, Toru Takumi
  • Organizer: The 32ndNaito Conference
  • Place of Presentation: Hokuto, Yamanashi
  • Year and Date: 20111018-21
• [Presentation] Rhythm and the blues (2011)
  • Author(s): Toru Takumi
  • Organizer: Worldsleep 2011
  • Place of Presentation: KyotoSymposium
  • Year and Date: 20111016-20
• [Presentation] Genome-wide profiling of the core clock protein BMAL1 targets reveals strict relationship with metabolism (2011)
  • Author(s): Fumiyuki Hatanaka, Chiaki Matsubara, Jihwan Myung, Takashi Yoritaka, Naoko Uemura, Shuichi Tsutsumi, Akinori Kanai, Yutaka Suzuki, Hiroyuki Aburatani, Sumio Sugano, Toru Takumi
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 20110914-17