2012 Fiscal Year Final Research Report
Establishment of the diagnostics of Alzheimer' s disease using A・43
| Project/Area Number |
23650185
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Nerve anatomy/Neuropathology
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
SAITO Takashi 独立行政法人理化学研究所, 神経蛋白制御研究チーム, 副チームリーダー (90360552)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | アルツハイマー病 / トランスレーショナルリサーチ / 早期診断 |
|---|
| Research Abstract |
Establishment of an early diagnosis for Alzheimer’s disease (AD) is one of the important missions in an aging society. Recently, we found that Ass43 is generated under an age-dependent manner, thereby it might be a good candidate as a marker for an early diagnosis of AD. Herein, we established a high-sensitive and quantitative method to detect Ass43 specifically in the sample from mice and human materials. Finally, we concluded that Ass43 has a potent pathogenicity, and would be an useful candidate for an early diagnosis for AD.
|
