2012 Fiscal Year Final Research Report
Microglial subtypes: Identification and characterization of their roles in emotional functions
| Project/Area Number |
23650190
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Nagoya University |
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Principal Investigator |
SAWADA Makoto 名古屋大学, 環境医学研究所, 教授 (10187297)
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| Co-Investigator(Renkei-kenkyūsha) |
ONO Kenji 名古屋大学, 環境医学研究所, 助教 (80329698)
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| Project Period (FY) |
2011 – 2012
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| Keywords | グリア細胞 / ミクログリア / サブタイプ / 精神活動 / グリア神経相関 |
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| Research Abstract |
Although Hoxb8-lineage microglia are indicated to be involved in the obsessive-compulsive disorder spectrum disorder, there are few lines of evidence between microglia and emotional regulation. In this project I indicated that cloned microglia and a part of bone marrow progenitorcells expressed Hoxb8. Injection of these cells directly into striatum improved stress-vulnerability in the forced-swimming stressed mice. These results suggest that microglia may be involved in stress-regulation of higher brain functions.
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Journal Title
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Journal Title
Journal of Neuroscience
Volume: 31
Pages: 12963-12971
Peer Reviewed
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