2012 Fiscal Year Final Research Report
Development of hemodiagnostic methods for Alzheimer's disease using curcuimin derivatives
| Project/Area Number |
23650192
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
TOOYAMA Ikuo 滋賀医科大学, 分子神経科学研究センター, 教授 (20207533)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 神経変性疾患 / 認知症 / アルツハイマー病 / 診断 / ベータアミロイド |
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| Research Abstract |
We have developed a novel curcumin derivative (Shiga-Y5), that can exist in an equilibrium between keto and enol tautomers, with the enol form able to bind Aβ aggregates while the keto form cannot. Using Shiga-Y5, we developed a hemodiagnostic method to detect Aβ deposition in the Tg2576 mouse, a model of AD. When Shiga-Y5 injected into tail veins of Tg2576 and wild mice, a delayed decreaserate of Shiga-Y5 clearance was observed in Tg2576 mice in comparison to wild-type mice. The delayed clearance of Shiga-Y5 from the brain into blood reflected amounts of Aβ depositions in the brain.
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Research Products
(8 results)
