2013 Fiscal Year Final Research Report
Development of nucleic acid medicines targeted to generally metastasized cancer cells using collagen derivatives
| Project/Area Number |
23650255
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Japan Advanced Institute of Science and Technology |
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Principal Investigator |
ODA Kazushi 北陸先端科学技術大学院大学, マテリアルサイエンス研究科, 助教 (30293400)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUKAHARA Toshifumi 北陸先端科学技術大学院大学, マテリアルサイエンス研究科, 教授 (60207339)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ナノバイオロジー / ナノメディスン / ガン細胞標的核酸試薬 |
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| Research Abstract |
Cationated collagen by acid treatment or by chemically modification is analyzed in transformation efficiency using cultured cells. Several derivatives of collagen alone did not show raise of transformation efficiency. Several additives are tested and optimal condition are elucidated. Around 10% raise in efficiency of transformation . Although 10 to 20 amino acid peptides for oral dose are tested for transformation, no samples showed outstanding raise in transformation efficiency.
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