2013 Fiscal Year Final Research Report
Development of contrast agents that image tumor-specific protease for Overhauser effect-enhaced MRI
| Project/Area Number |
23650266
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kumamoto University (2012-2013)
Kyushu University (2011) |
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Principal Investigator |
NIIDOME Takuro 熊本大学, 自然科学研究科, 教授 (20264210)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 医用・生体画像 / バイオイメージング / MRI / オーバーハウザー効果 / 腫瘍 / プロテアーゼ |
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| Research Abstract |
Overhauser-enhanced MRI (OMRI) is a double resonance technique that uses the presence of paramagnetic agents such as nitroxyl radicals to enhance the signal intensity from nuclear spins by a process known as the Overhauser effect. In this study, dendritic poly(L-lysine) polymers were modified with stable nitroxyl radicals through substrate peptides of a protease specifically expressed in tumors. Cleavage of the peptides by the protease affected the OMRI signal from the radicals. This system could be the basis of a functional tumor imaging technique by OMRI.
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[Journal Article] Cancer-specific gene carriers responding to cancer microenvironment : acidosis and hyper-activated protein kinases2013
Author(s)
S. Kushio, A. Tsuchiya, Y. Nakamura, T. Nobori, C. W. Kim, G. X. Zhao, T. Funamoto, E. K. Lee, T. Niidome, T. Mori, Y. Katayama
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Journal Title
Biomed. Eng-App. Bas. C
Volume: 25
Pages: 1340005
Peer Reviewed
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[Journal Article] Stabilization of cancer-specific gene carrier via hydrophobic interaction for a clear-cut response to cancer signaling2013
Author(s)
C. W. Kim, R. Toita, J.-H. Kang, K.Li, E. K. Lee, G. X. Zhao, D. Funamoto, T. Nobori, Y. Nakamura, T. Mori, T. Niidome, Y. Katayama
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Journal Title
J. Controlled Release
Volume: 170
Pages: 469-476
Peer Reviewed
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[Journal Article] Branched polyethylenimine-based PKCα-responsive gene carriers2013
Author(s)
Y. Nakamura, C. W. Kim, A. Tsuchiya, S. Kushio, T. Nobori, K. Li, E. K. Lee, G. X. Zhao, D. Funamoto, T. Niidome, T. Mori, Y. Katayama
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Journal Title
J. Biomater. Sci.-Polym. Ed
Volume: 24
Pages: 1858-1868
Peer Reviewed
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