2012 Fiscal Year Final Research Report

Measurement of platelet activation process on shear blood flows and modeling of thrombus formation process

Research Project

Project/Area Number	23650268
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Biomedical engineering/Biological material science
Research Institution	Kyushu Institute of Technology
Principal Investigator	TAMAGAWA Masaaki 九州工業大学, 大学院・生命体工学研究科, 教授 (80227264)
Project Period (FY)	2011 – 2012
Keywords	バイオメカニクス / 医用流体機械
Research Abstract	In this investigation, thrombus formation process is modeled as three step process, which are activation of platelet, transport of activated platelet and adhesion of platlet to the wall and polymerization. Especially, the dependency of shear rate on the platelet activation was focused in this project. From this project, it is concluded that (1) By working averaged shear rate from 100 to 200 (1/s), thrombus can be found at the wall, and the higher the shear rate becomes, the more thrombus formation rate increases (2) By observation of luminescence with aequorin for detecting platelet-activation, the amplitude of luminescence is too low level comparing with background (SIN ratio) even if changing optical settina up.