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2012 Fiscal Year Final Research Report

Development of antibody recognition imaging method for cancer diagnosis

Research Project

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Project/Area Number 23650271
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biological material science
Research InstitutionKeio University

Principal Investigator

YANAGAWA Hiroshi  慶應義塾大学, 理工学部, 訪問教授 (40327672)

Co-Investigator(Kenkyū-buntansha) TABATA Noriko  慶應義塾大学, 理工学研究科, 特任准教授 (60260080)
Project Period (FY) 2011 – 2012
KeywordsiPS細胞 / がん幹細胞 / in vitro virus法 / CD44 / in vivo imaging
Research Abstract

Since CD44 is considered to be one of the factors required in order to maintain the autonomous replication ability of cancer stem cells as adhesion molecules, we performed to select single strand antibodies which prevent the induced cancer stem

  • Research Products

    (9 results)

All 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (4 results) Book (2 results)

  • [Journal Article] DNA display selection of peptide ligands for a full-length human G protein-coupled receptor on CHO-K1 cells2012

    • Author(s)
      Doi, N., Yamakawa, N., Matsumoto, H., Yamamoto, Y., Nagano, T., Matsumura, N., Horisawa, K., Yanagawa, H.
    • Journal Title

      PLoS ONE

      Volume: 7 Pages: e30084

    • DOI

      DOI:10.1371/ journal.pone.0030084

    • Peer Reviewed
  • [Journal Article] A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma2012

    • Author(s)
      Shiheido, H., Terada, F., Tabata, N., Hayakawa, I., Matsumura, N., Takashima, H., Ogawa, Y., Du, W., Yamada, T., Shoji, M., Sugai, T., Doi, N.,Iijima, S., Hattori, Y., Yanagawa, H.
    • Journal Title

      PLoS ONE

      Volume: 7 Pages: e38878

    • DOI

      DOI:10.1371/journal.Pone.0038878

    • Peer Reviewed
  • [Journal Article] In vitro selection of Fab fragments by mRNA display and gene-linking emulsion PCR2012

    • Author(s)
      Sumida, T., Yanagawa, H., Doi, N.
    • Journal Title

      J. Nucleic Acids

      Volume: 2012 Pages: 371379

    • DOI

      DOI:10.1155/2012/371379

    • Peer Reviewed
  • [Presentation] In vitroevolution of high-affinity anti-CCR5 single chain Fv via neutral drift libraries2011

    • Author(s)
      Sato, R., Doi,N., Misumi,S., Shoji,S., Matsushima, S., Yokochi, S., Yanagawa, H.
    • Organizer
      34th MBSJ 2011
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-12-13
  • [Presentation] In vitroselection of anti-CD44v scFv inhibiting CD44v-xCT interaction2011

    • Author(s)
      Umezawa,H., Tabata,N., Sakuma,Y., Takenaka,Y., Matsumoto,Y., Doi,N., Nagano, O., Saya,H., Yanagawa, H.
    • Organizer
      34th MBSJ 2011
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-12-13
  • [Presentation] In vitroselection of Fc receptor-binding peptides using in vitro virus method2011

    • Author(s)
      Mihara, M., Sumida, T., Sakuma, Y., Tabata, N., Horisawa, K., Yanagawa, H., Doi, N.
    • Organizer
      34th MBSJ 2011
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-12-11
  • [Presentation] Selection of scFv inhibiting adhesion of induced cancer stem cells by in vitro virus (IVV) method2011

    • Author(s)
      Tabata, N., Sakuma, Y., Shimizu, T., Saya, H., Doi, N., Yanagawa, H.
    • Organizer
      34th MBSJ 2011
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-12-11
  • [Book] Chemical Synthetic Biology2011

    • Author(s)
      Doi, N., Kakukawa, K., Oishi, Y., Yanagawa, H. John Wiley & Sons
    • Total Pages
      121-138
    • Publisher
      Ltd.
  • [Book] Neural Stem Cells and Therapy2011

    • Author(s)
      Horisawa,K., Yanagawa, H
    • Total Pages
      205-222
    • Publisher
      InTech

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Published: 2014-08-29   Modified: 2014-10-02  

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