2012 Fiscal Year Final Research Report

Development of visualization of soft tissue morphology and protein concentration by X-ray phase-contrast computed tomography.

Research Project

Project/Area Number	23650277
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Biomedical engineering/Biological material science
Research Institution	Kawasaki Medical School
Principal Investigator	MOHRI Satoshi 川崎医科大学, 医学部, 教授 (00294413)
Co-Investigator(Kenkyū-buntansha)	HASHIMOTO Ken 川崎医科大学, 医学部, 講師 (80341080) UJIHARA Yoshihiro 川崎医科大学, 医学部, 助教 (80610021)
Co-Investigator(Renkei-kenkyūsha)	UESUGI Kentaro (財)高輝度光科学研究センター, 研究員 (80344399)
Project Period (FY)	2011 – 2012
Keywords	位相差 CT / X 線 / タンパク濃度
Research Abstract	Clinical X-ray computed tomography (CT) is based on the absorption of X-rays as they pass through the different parts of a patient's body. In this study, we developed phase-contrast X-ray CT that enables to visualize the fine texture of soft tissues that include similar X-ray absorbance materials. Moreover, we could firstly evaluate the concentration gradient of lens protein that enables to correct for spherical aberration. This method may provide new information about vital function.

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