2012 Fiscal Year Final Research Report
Super cell-specific gene delivery system using triple securities
| Project/Area Number |
23650290
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 遺伝子送達 / DDS / 遺伝子治療 / がん / プロテインキナーゼ |
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| Research Abstract |
In this research, we attempted to improve cell specificity of gene delivery system with multiple securities. Thus, cationic polyethyleneimine and hydrophobic chain were introduced into our previously developed intracellular signal-responsive gene carrier. The carrier improved cancer cell specificity dramatically. Then, PEG chains were also incorporated into the carrier with pH-labile manner to stabilize the polyplex with DNA in blood circulation. Obtained carrier realized 1300 times activation in cancer cell against normal cell condition.
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[Journal Article] Cancer-specific gene carriers responding to cancer microenvironment: acidosis and hyper-activated protein kinases
Author(s)
S. Kushio, A. Tsuchiya, Y. Nakamura, T. Nobori, C. W. Kim, G. Zhao, D. Funamoto, E. K. Lee, K. Lee, T. Niidome, T. Mor, Y. Katayama
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Journal Title
Biomed. Eng
Volume: (in press)
Peer Reviewed
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