2012 Fiscal Year Final Research Report
One-pot preparation of dendrimer-gold nanohybrids with controlled photothermal property and their application to cancer therapy
| Project/Area Number |
23650293
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
KONO Kenji 大阪府立大学, 大学院・工学研究科, 教授 (90215187)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ナノバイオ / デンドリマー / 金ナノ粒子 / 癌治療 |
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| Research Abstract |
In this study, we attempted to develop dendrimer-gold nanorod hybrids with controlled size and photothermal property. The hybrids with small size and high photothermal property were prepared by formation of gold nanorod in the presence of polyethyelen glycol-modified polyamidoamine dendrimers with disulfide bond at the core. Cancer cells taking up the hybrids were killed effectively under near infrared light irradiation and hence these hybrids might be potentially useful as a nanodevice for photothermal therapy for cancer.
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[Journal Article] Assemblies of polyamidoamine dendron-bearing lipids with various generations: their morphologies and abilities of gene transfection2012
Author(s)
S. Iwashita, Y. Hiramatsu, T. Otani, C. Amano, M. Hirai, H. Minematsu, H. Kitagawa, K. Oie, E. Yuba, K. Kono, M. Miyamoto, K. Igarashi
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Journal Title
J. Biomaterials Applications
Volume: 27
Pages: 445-456
Peer Reviewed
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