2013 Fiscal Year Final Research Report
Molecular basis of epigenetic regulation by ultrasound
| Project/Area Number |
23650303
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical systems
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| Research Institution | University of Toyama |
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Principal Investigator |
TABUCHI Yoshiaki 富山大学, 生命科学先端研究センター, 准教授 (20322109)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Takashi 富山大学, 大学院・医学薬学研究部 (医学), 教授 (40143937)
WADA Shigehito 富山大学, 大学病院, 講師 (50303219)
IKEGAME Mika 岡山大学, 医歯(薬)学総合研究科, 准教授 (70282986)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 超音波 |
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| Research Abstract |
Low-intensity pulsed ultrasound (LIPUS) has been used extensively as an adjuvant to fracture healing. We identified many up-regulated genes that were associated with bone morphology in mouse osteoblast cells treated with a single 20-min LIPUS (1.5 MHz, 30 mW/cm2) using global-scale gene expression analyzing technologies. These results obtained here should help to further clarify the molecular basis of the mechanisms of the LIPUS response in osteoblast cells.
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Research Products
(12 results)
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[Journal Article] Development of oral epithelial cell line ROE2 with differentiation potential from transgenic rats harboring temperature-sensitive simian virus40 large T-antigen gene2014
Author(s)
Tabuchi Y, Wada S, Ikegame M, Kariya A, Furusawa Y, Hoshi N, Yunoki T, Suzuki N, Takasaki I, Kondo T, Suzuki Y
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Journal Title
Exp. Anim
Volume: Vol.63,No.1
Pages: 31-44
DOI
Peer Reviewed
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[Journal Article] DNA double-strand breaks induced by cavitational mechanical effects of ultrasound in cancer cell lines2012
Author(s)
Furusawa Y, Fujiwara Y, Campbell P, Zhao QL, Ogawa R, Hassan MA, Tabuchi Y, Takasaki I, Takahashi A, Kondo T
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Journal Title
PLoS One
Volume: Vol.7,No.1
Pages: e29012
DOI
Peer Reviewed
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