Protective effects of exercise on muscle wasting caused by cachexia

2012 Fiscal Year Final Research Report

• Project/Area Number: 23650324
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kobe University
• Principal Investigator: FUJINO Hidemi 神戸大学, 大学院・保健学研究科, 教授 (20278998)
• Co-Investigator(Kenkyū-buntansha): ISHIHARA Akihiko 京都大学, 大学院・人間環境学研究科, 教授 (90184548) ; MURAKAMI Shinichiro 姫路獨協大学, 医療保健学部, 准教授 (30454763) ; KONDO Hiroyo 名古屋女子大学, 家政学部, 講師 (50333183)
• Project Period (FY): 2011 – 2012
• Keywords: 筋萎縮 / 運動 / 悪液質 / サイトカイン

Research Abstract

The purpose of this study is to investigate the effects of exercise on muscle wasting caused by disuse and cancer. Cachexia resulted in the reduction of muscle cross-sectional area and metabolic enzyme, and the overexpression of TNF-α and atrogin-1/MAFbx. Exercise training attenuates muscle atrophy and the overexpression of TNF-α and atrogin-1/MAFbx. Thus, exercise training attenuates muscle wasting associated with some catabolic conditions. These results provide further evidence for the effects of exercise on muscle wasting. It was found that not only resistance exercise protocols, but also chronic endurance exercises could attenuate skeletal muscle wasting induced by disuse and cancer through down-regulation of TNF-α and indirect down-regulation of atrogin-1/MAFbx gene expression.

Research Products

• [Journal Article] Comparison of premodulated interferential and pulsed current electrical stimulation in prevention of deep muscle atrophy in rats (2013)
  • Author(s): Tanaka M, Hirayama Y, Fujita N, Fujino H
  • Journal Title: J Mol Histol Volume: 44 Pages: 203-211
• [Journal Article] Influence of magnetic stimulation on muscle atrophy in the rat unloading hindlimb muscles (2012)
  • Author(s): Fujiwara Y, Arakawa T, Fujita N, Fujino H, Miki A
  • Journal Title: Bulletin Health Sciences Kobe Volume: 27 Pages: 19-26
• [Journal Article] Fujino H, Kondo H, Murakami S, Nagatomo F, Fujita N, Takeda I, Ishihara A, Roy RR (2012)
  • Author(s): Differences in capillary architecture, hemodynamics, and angiogenic factors in rat slow and fast plantarflexor muscle
  • Journal Title: Muscle Nerve Volume: 45 Pages: 242-249
• [Journal Article] Oxidative stress levels in rats depending on oxygen concentrations (2012)
  • Author(s): Nagatomo F, Fujino H, Kondo H, Ishihara A
  • Journal Title: Oxid Med Cell Long Volume: 2012 Pages: 381763-8
• [Journal Article] Chronic exercise training down-regulates TNF-αand atrogin-1/MAFbx in mouse gastrocnemius muscle atrophy induced by hindlimb unloading. (2012)
  • Author(s): Saad Al-Nassan, Fujita N, Kondo H, Murakami S, Fujino H
  • Journal Title: Acta Histochem Cytochem Volume: 45 Pages: 343-349
• [Journal Article] Lifestyle-related disease and skeletal muscle: A review (2012)
  • Author(s): Ishihara A, Nagatomo F, Fujino H, Kondo H, Tsuda K
  • Journal Title: J Phys Fitness Sports Med Volume: 1 Pages: 1-11
• [Journal Article] The combined effect of electrical stimulation and high-load isometric contraction on protein degradation pathways in muscle atrophy induced by hindlimb unloading (2011)
  • Author(s): Fujita N, Murakami S, Fujino H
  • Journal Title: J Biomed Biotechnol
  • DOI: DOI:10.1155/2011/ 401493
• [Journal Article] The combined effect of electrical stimulation and resistance isometric contraction on muscle atrophy in rat tibialis anterior muscle (2011)
  • Author(s): Fujita N, Murakami S, Arakawa T, Miki A, Fujino H
  • Journal Title: Bosn J Basic Med Sci Volume: 11(2) Pages: 1-6
• [Presentation] ラット下腿深層筋の萎縮に対する矩形波及び正弦波電気刺激の予防効果 (2012)
  • Author(s): 田中稔,平山佑介,藤田直人,藤野英己
  • Organizer: 第20回日本物理療法学会学術大会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-27
• [Presentation] Ameliorative effects of antioxidant astaxanthin on capillary regression in hindlimb unloading-induced atrophied muscle (2012)
  • Author(s): Fujino H, Kanazashi M, Kondo H, Murakami S, Nagatomo F, Fujita N, Ishihara A
  • Organizer: Integrative Biology of Exercise VI
  • Place of Presentation: Westminster
  • Year and Date: 2012-10-10
• [Presentation] 廃用性筋萎縮におけるミトコンドリア機能低下に対する荷重及びアスタキサンチン併用の効果 (2012)
  • Author(s): 金指美帆,藤田直人,藤野英己
  • Organizer: 第67回日本体力医学会
  • Place of Presentation: 岐阜
  • Year and Date: 2012-09-14
• [Presentation] 中周波および低周波電気刺激が後肢非荷重ラットの深層骨格筋における毛細血管退行に及ぼす影響 (2012)
  • Author(s): 平山佑介,田中稔,藤田直人,村上慎一郎,近藤浩代,永友文子,石原昭彦,藤野英己
  • Organizer: 第20回日本運動生理学会
  • Place of Presentation: 筑波
  • Year and Date: 2012-07-28
• [Presentation] (2012)
  • Author(s): 田中稔,平山佑介,藤田直人,村上慎一郎,近藤浩代,永友文子,石原昭彦,藤野英己
  • Organizer: 第20回日本運動生理学会
  • Place of Presentation: 筑波
  • Year and Date: 2012-07-28
• [Presentation] 異なる運動強度が遅筋・速筋の毛細血管新生及び代謝活性に与える影響 (2012)
  • Author(s): 田中雅侑,村上慎一郎,藤田直人,近藤浩代,永友文子,石原昭彦,藤野英己
  • Organizer: 第20回日本運動生理学会
  • Place of Presentation: 筑波
  • Year and Date: 2012-07-28
• [Presentation] Effect Of Aerobic Training On Three-dimensional Capillary Architecture In Soleus Muscle (2012)
  • Author(s): Murakami S, Fujita N, Morifuji T, Kondo H, Fujino H
  • Organizer: 59th American College of Sports Medicine. Medicine & Science in Sports & Exercise
  • Place of Presentation: San Francisco
  • Year and Date: 2012-05-29
• [Presentation] Antioxidant Supplementation to Prevent The Progression of Microangiopathy in Hindlimb Unloading-induced Atrophied Soleus Muscle in Rats (2012)
  • Author(s): Fujino H, Kanazashi M, Kondo H, Murakami S, Fujita N, Nagatomo F, Ishihara A
  • Organizer: 59th American College of Sports Medicine. Medicine & Science in Sports & Exercise
  • Place of Presentation: San Francisco
  • Year and Date: 2012-05-29
• [Presentation] 長期間の持久運動はマウス腓腹筋の廃用性筋萎縮に伴うTNF-αとatrogin-1/MAFbxの発現を抑制する (2012)
  • Author(s): Al-Nassan Saad,藤田直人,近藤浩代,村上慎一郎,藤野英己
  • Organizer: 第47回日本理学療法学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2012-05-25
• [Presentation] Preventive effects of premodulated interferential and pulsed currents on muscle atrophy in deep layer of rat hindlimb muscle (2012)
  • Author(s): Tanaka M, Fujita N, Fujino H
  • Organizer: Experimental Biology 2012
  • Place of Presentation: San Diego
  • Year and Date: 2012-04-24
• [Presentation] Three-dimensional visualization of capillary and prevention of capillary regression by antioxidant supplementation in disused skeletal muscle (2011)
  • Author(s): Fujino H, Kanazashi M, Kondo H, Murakami S, Nagatomo F, Fujita N, Ishihara A
  • Organizer: The 51th annual meeting of American society for cell biology
  • Place of Presentation: Denver
  • Year and Date: 2011-12-03
• [Presentation] ラット後肢深層筋の廃用性萎縮に対する中周波及び低周波電気刺激の予防効果 (2011)
  • Author(s): 田中稔,藤田直人,藤野英己
  • Organizer: 第19回日本物理療法学会学術大会
  • Place of Presentation: 徳島
  • Year and Date: 2011-10-15
• [Presentation] 廃用性筋萎縮の予防に対する等尺性収縮を用いた治療的電気刺激の効果 (2011)
  • Author(s): 藤田直人,村上慎一郎,藤野英己
  • Organizer: 第19回日本物理療法学会学術大会
  • Place of Presentation: 徳島
  • Year and Date: 2011-10-15
• [Presentation] Benefical effect of nutritional support against regression of capillary network in atrophied slow muscle (2011)
  • Author(s): Kanazashi M, Okumura Y, Fujita, Murakami S, Fujino H
  • Organizer: The World Confederation for Physical Therapy 2011
  • Place of Presentation: Amsterdam
  • Year and Date: 2011-06-20
• [Presentation] Protective effects of isometric contraction using electrical stimulation on muscle atrophy (2011)
  • Author(s): Fujita N, Fujino H
  • Organizer: The World Confederation for Physical Therapy 2011
  • Place of Presentation: Amsterdam
  • Year and Date: 2011-06-20
• [Book] 運動生理学のニューエビデンス(宮村実晴 編) (2010)
  • Author(s): 藤野英己・他54名
  • Total Pages: 250-258
  • Publisher: 真興交易医書出版部(東京)
• [Remarks]
  • URL: http://www.research.kobe-u.ac.jp/fhs-fujino/