2012 Fiscal Year Final Research Report

The evaluation of exercise effect in muscle atrophy by development of muscular strength measuring device for mice

Research Project

Project/Area Number	23650339
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Rehabilitation science/Welfare engineering
Research Institution	Nagoya Gakuin University
Principal Investigator	HIRANO Takayuki 名古屋学院大学, リハビリテーション学部, 教授 (10440661)
Co-Investigator(Kenkyū-buntansha)	ITOH Yuta 名古屋学院大学, リハビリテーション学部, 助教 (30454383)
Project Period (FY)	2011 – 2012
Keywords	理学療法学 / 筋萎縮 / 筋力 / マウス
Research Abstract	We developed the equipment which can noninvasively and sequentially measure the maximum Plantar-flexion torque of mouse, and investigated the relationship between histological effect and the functional effect of resistance exercise (RE) in facilitating recovery from the muscle atrophy. As a result, the histological effect from the muscle atrophy by RE was observed in the myofiber cross sectional area of the soleus muscle. However, the functional effect in plantar-flexion torque was not able to be observed, suggesting that the difference is due to the histological change of other plantar-flexior muscles were small. However, the torque change by muscle atrophy or its recovery process has been sequentially evaluated by using this equipment.

(4 results)