2012 Fiscal Year Final Research Report

Non-invasive, continuous measurement for intermediate metabolite and ion dynamics of skeletal muscle during muscle contraction

Research Project

Project/Area Number	23650408
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Sports science
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	KIMURA Misaka 京都府立医科大学, 医学部, 教授 (90150573)
Project Period (FY)	2011 – 2012
Keywords	生体電気インピーダンス分光法 / 骨格筋 / 細胞内液 / 細胞外液 / 運動
Research Abstract	The aim of this study is explore the possibility of using segmental multi-frequency bioelectrical impedance spectroscopy (S-BIS) to measure the dynamics of metabolism in human skeletal muscle. We examined the application of non-invasive measurement of water distribution using electrical property of cell membrane in skeletal muscle. During exercise, intra-cellular water rapidly increased and extra-cellular water decreased at the time of decreasing oxygenated hemoglobin in the tissue. From the results of several experiments, S-BIS has a possibility to detect the dynamics of metabolism in skeletal muscle during exercise.