Regulation of adipocyte differentiation by Wnt signaling pathway

2014 Fiscal Year Final Research Report

• Project/Area Number: 23650487
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Eating habits, studies on eating habits
• Research Institution: Osaka City University
• Principal Investigator: KIM DONGHO 大阪市立大学, 大学院生活科学研究科, 准教授 (70326271)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Keywords: リポ蛋白質受容体 / Wntシグナル / 食品因子 / 脂肪細胞

Outline of Final Research Achievements

Adipocytes are critically involved in enhancing the clinical risk of metabolic syndrome. Adipocytes can arise from mesenchymal stem cells (MSCs) that can differentiation to many cell types such as adipocytes, bone, cartilage, tendon, muscle, skin, and nerves. Wnts are secreted signaling proteins that regulate differentiation into osteoblast of MSCs. On the other hand, peroxisome proliferator-activated receptor γ (PPARγ) is a critical factor for adipogenesis. PPARγ agonists are induces the differentiation into adipocyte of MSCs but Wnts are inhibit the adipocyte differentiation. Wnt proteins are comprised a large family of nineteen proteins and highly conserved in many species. To date major signaling branches downstream of the Fz receptor have been identified including a canonical or Wnt/β-catenin dependent pathway and the non-canonical or β-catenin-independent pathway. Here we show that role of the Wnt signaling in the differentiation mechanism from the MSC into adipocytes.

Free Research Field

分子栄養学