2012 Fiscal Year Final Research Report
Analysis of the ability for memory-learning from a stand point of nutrrhythm and its basic research for prevention of senile dementia
| Project/Area Number |
23650490
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kagawa Nutrition University |
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Principal Investigator |
HORIE Shuichi 女子栄養大学, 栄養学部, 教授 (60157063)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUSHIMA Mami 女子栄養大学, 栄養学部, 助教 (30286885)
HIRAISHI Sayuri 女子栄養大学, 栄養科学研究所, 助教 (20150659)
KAGAWA Yasuo 女子栄養大学, 栄養学部, 教授 (30048962)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 食行動 / 認知症 / 記憶学習能力 / 高脂肪食 / 時計遺伝子 |
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| Research Abstract |
We examined the effect of a high-fat (HF) diet on learning and memory functions in clock-mutant mice (clock) comparing its wild mice (wild) by measuring passive avoidance test (PAT) and by using Morris Water Maze apparatus. In the results, not only clockmice fed on the control diet, but also wild female mice fed on the HF diet were impaired the retention for PAT. It became obvious that female mice, with respect to memory retention, are more susceptible to HF diet and that entrainment of the peripheral circadian rhythm is essential for maintenance of learning and memory functions in mice.
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