2011 Fiscal Year Final Research Report
Understanding of molecular mechanisms regulating leukemia stem cell behavior by multi-omics analysis
| Project/Area Number |
23650593
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Tumor biology
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
HIRAO Atsushi 金沢大学, がん進展制御研究所, 教授 (90343350)
|
|---|
| Project Period (FY) |
2011
|
| Keywords | 白血病幹細胞 / mTOR |
|---|
| Research Abstract |
mTOR is an evolutionarily conserved kinase in eukaryotes that plays a critical role in sensing and responding to factors such as nutrient availability, energy sufficiency, stress, hormones, and mitogens. Since it was reported that mTOR complex 1(mTORC1) dysregulation promotes leukemogenesis and depletes hematopoietic stem cells, we attempted to understand the pathological roles of mTORC1 in leukemia behavior by multi-omics technology. In this study, we found that there are particular cell population showing obvious resistance to mTORC1 inactivation, and found several candidate molecules that are involved in the regulation of leukemia stem cells.
|
-
-
-
-
-
[Journal Article] Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer2011
Author(s)
El Ghamrasni S, Pamidi A, Halaby MJ, Bohgaki M, Cardoso R, Li L, Venkatesan S, Sethu S, Hirao A, MakTW, Hande MP, Hakem A, Hakem R.
-
Journal Title
DOI
Peer Reviewed
-
[Journal Article] Invasion precedestumor mass formation in a malignant brain tumor model of genetically modified neural stem cells2011
Author(s)
Sampetrean O, Saga I, Nakanishi M, Sugihara E, Fukaya R, Onishi N, Osuka S, Akahata M, Kai K, Sugimoto H, Hirao A, Saya H.
-
Journal Title
Neoplasia.
Volume: 13
Pages: 784-91
DOI
Peer Reviewed
-
[Journal Article] Transientdepletion of p53 followed by transduction of c-Myc and K-Rasconverts ovarian stem-like cells into tumor-initiating cells2011
Author(s)
Motohara T, Masuko S, Ishimoto T, Yae T, Onishi N, Muraguchi T, Hirao A, Matsuzaki Y, Tashiro H, Katabuchi H, Saya H, Nagano O.
-
Journal Title
Carcinogenesis.
Volume: 32
Pages: 1597-606
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
