2012 Fiscal Year Final Research Report
Development and analysis of human monoclonal antibodies derived from patients with cancer
| Project/Area Number |
23650607
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor immunology
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| Research Institution | University of Toyama |
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Principal Investigator |
ISOBE Masaharu 富山大学, 大学院・理工学研究部, 教授 (70211050)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ヒトモノクローナル抗体 / 免疫学 / 癌 / MAGrahd法 |
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| Research Abstract |
It has been known that the elevation of autoantibodies can frequently be observed in patients with cancer along with its progression. Among those some are potentially useful for the development of therapeutic or diagnostic antibodies for cancer. Recent development of our high-throughput isolation system of human monoclonal antibodies enabled us for the construction of antibody libraries from cancer patients derived antibody-producing single cells. The binding specificity of each antibody was examined by staining the cancer tissue from the same patient. After extensive screening we have succeeded in isolation of multiple antibodies that recognize cancer cells.
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Research Products
(18 results)
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[Journal Article] Reduced Level of the BCL11B Protein Is Associated with Adult T-Cell Leukemia/Lymphoma2013
Author(s)
Kurosawa, N., Fujimoto, R., Ozawa, T., Itoyama, T., Sadamori, N., and Isobe, M.
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Journal Title
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[Journal Article] HELIOS-BCL11B fusion gene involvement in a t(2;14)(q34;q32) in an adult T-cell leukemia patient2012
Author(s)
Fujimoto, R., Ozawa, T., Itoyama, T., Sadamori, N., Kurosawa, N., and Isobe, M.
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Journal Title
Cancer genetics
Volume: 205
Pages: 356-364
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