2012 Fiscal Year Final Research Report
Development of endoscopic molecular imaging diagnostic procedure for esophageal cancer using real-time virtual molecular biology
| Project/Area Number |
23650616
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Tumor diagnosis
|
|---|
| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NOSHO Katsuhiko 札幌医科大学, 医学部, 助教 (10597339)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 食道扁平上皮癌 / DNA / メチル化 / microRNA / 背景粘膜 / 粘膜内癌 |
|---|
| Research Abstract |
The aim of this study was to profile methylation changes and identify methylated genes and to clarify the role of genome-wide hypomethylation in esophageal squamous cell carcinoma(ESCC).The degree of genome-wide CpG islands methylation increased from the normal healthy epithelium,through the ESCC-background non-neoplastic epithelium,to the carcinoma tissues.CpG island hypermethylation of tumor-related genes,especially that of the LRFN5 gene,and genome-wide hypomethylation appear to play important roles in ESCC pathogenesis irrespective of drinking and/or smoking habits.
|
