2012 Fiscal Year Final Research Report
Innovative improvement of cancer therapeutic adenovirus vector carrying REIC gene
| Project/Area Number |
23650625
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Clinical oncology
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
HUH Namho 岡山大学, 大学院・医歯薬学総合研究科, 教授 (70142023)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SAKAGUCHI Masakiyo 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70379840)
KATAOKA Ken 岡山理科大学, 理学部, 准教授 (10293317)
MURATA Hitoshi 岡山大学, 大学院・医歯薬学総合研究科, 助教 (90579096)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | がん遺伝子治療 / アデノウイルス / REIC |
|---|
| Research Abstract |
Adenovirus vector is one of the most widely used vectors for cancer gene therapies. One of the serious problems associated with adenovirus vector-based gene therapy is that expression of Coxsackievirus and Adenovirus Receptor (CAR), a receptor for the adenovirus vector, is often reduced among advanced cancers. In this study, we attempted to highly enhance expression of a cargo gene by modifying promoter and applying a developed adenovirus-adaptor protein. A newly designed Ad-REIC showed 10 to 100 fold higher expression in a cancer specific manner than that attained by previous one. This vector certainly improved the therapeutic effect for a wide variety of human cancers. The selective anti-cancer function of the new Ad-REIC shows a great promise for clinical application.
|
Research Products
(20 results)
-
-
-
-
-
-
-
-
-
-
[Journal Article] Tumor suppressor REIC/Dkk-3 interacts with the dynein light chain, Tctex-12011
Author(s)
Ochiai K, Watanabe M, Ueki H, Huang P, Fujii Y, Nasu Y, Noguchi H, Hirata T, Sakaguchi M, Huh NH, Kashiwakura Y, Kaku H, Kumon H
-
Journal Title
Biochem Biophys Res Commun
Volume: 412
Pages: 391-395
Peer Reviewed
-
[Journal Article] TIRAP, an Adaptor Protein for TLR2/4, Transduces a signal from RAGE Phosphorylated upon Ligand Binding2011
Author(s)
Sakaguchi M, Murata M, Yamamoto K, Ono T, Sakaguchi Y, Motoyama A, Hibino T, Kataoka K, Huh NH
-
Journal Title
PLoS ONE
Volume: 6
Pages: e23132
Peer Reviewed
-
[Journal Article] Epigenetic silencing of microRNA-34b/c plays an important role in the pathogenesis of malignant pleural mesothelioma2011
Author(s)
Kubo T, Toyooka S, Tsukuda K, Sakaguchi M, Fukazawa T, Soh J, Asano H, Ueno T, Muraoka T, Yamamoto H, Nasu Y, Kishimoto T, Pass HI, Matsui H, Huh NH, Miyoshi S
-
Journal Title
Clin Cancer Res
Volume: 17
Pages: 4965-4974
Peer Reviewed
-
-
[Journal Article] Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 suppresses peritoneal dissemination of scirrhous gastric carcinoma2011
Author(s)
Than SS, Kataoka K, Sakaguchi M, Murata H, Abarzua F, Taketa C, Du G, Yashiro M, Yanagihara K, Nasu Y, Kumon H, Huh NH
-
Journal Title
Oncol Rep
Volume: 25
Pages: 989-995
Peer Reviewed
-
-
-
-
-
-
